Guanfacine |
| カタログ番号GC14813 |
グアンファシンは、経口で活性なノルアドレナリン作動性 α2A アゴニストであり、α2A 受容体サブタイプに対して高い選択性を持っています。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 29110-47-2
Sample solution is provided at 25 µL, 10mM.
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Guanfacine is a selective α2A receptor agonist.Target: α2A ReceptorGuanfacine is a sympatholytic. It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone [1, 2].
References:
[1]. Kolar, D., et al., Treatment of adults with attention-deficit/hyperactivity disorder. Neuropsychiatr Dis Treat, 2008. 4(2): p. 389-403.
[2]. Zwieten, P.v., M. Thoolen, and P. Timmermans, The pharmacology of centrally acting antihypertensive drugs. British journal of clinical pharmacology, 1983. 15(Supplement s4): p. 455S-462S.
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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