Heptamethine cyanine dye-1 (ADS 815EI) |
| カタログ番号GC33541 |
Heptamethine cyanine dye-1 (ADS 815EI)は近赤外シアニン染料であり、その特徴は良い水溶性、低毒性、吸光/発光波長は約780/800nmである。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 162411-29-2
Sample solution is provided at 25 µL, 10mM.
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Heptamethine cyanine dye-1 (ADS 815EI)は近赤外シアニン染料であり、その特徴は良い水溶性、低毒性、吸光/発光波長は約780/800nmである[1][2]。Heptamethine cyanine dye-1 (ADS 815EI)は長い三重項状態寿命、高い一重項酸素量子収率と低い暗毒性を持ち、細胞内細胞内局在におけるミトコンドリアに標的能力を示し、TPPなど、幾つかの化合物を共役することで、良い腫瘍標的と生物利用度を示した[3][4]。これらの特性により、Heptamethine cyanine dye-1 (ADS 815EI)は、組織のイメージング、光線力学療法と薬物送達システムに適するようになる[5-7]。
References:
[1] Cheng, G., Fan, J., Sun, W., Cao, J., Hu, C., & Peng, X. (2014). A near-infrared fluorescent probe for selective detection of HClO based on Se-sensitized aggregation of heptamethine cyanine dye. Chemical communications (Cambridge, England), 50(8), 1018–1020.
[2] Pan, G. Y., Jia, H. R., Zhu, Y. X., Wang, R. H., Wu, F. G., & Chen, Z. (2017). Dual Channel Activatable Cyanine Dye for Mitochondrial Imaging and Mitochondria-Targeted Cancer Theranostics. ACS biomaterials science & engineering, 3(12), 3596–3606.
[3] Ning, J., Huang, B., Wei, Z., Li, W., Zheng, H., Ma, L., Xing, Z., Niu, H., & Huang, W. (2017). Mitochondria targeting and near-infrared fluorescence imaging of a novel heptamethine cyanine anticancer agent. Molecular medicine reports, 15(6), 3761–3766.
[4] Cooper, E., Choi, P. J., Denny, W. A., Jose, J., Dragunow, M., & Park, T. I. (2021). The Use of Heptamethine Cyanine Dyes as Drug-Conjugate Systems in the Treatment of Primary and Metastatic Brain Tumors. Frontiers in oncology, 11, 654921.
[5] Yang, X., Shi, C., Tong, R., Qian, W., Zhau, H. E., Wang, R., Zhu, G., Cheng, J., Yang, V. W., Cheng, T., Henary, M., Strekowski, L., & Chung, L. W. (2010). Near IR heptamethine cyanine dye-mediated cancer imaging. Clinical cancer research : an official journal of the American Association for Cancer Research, 16(10), 2833–2844.
[6] Jiao, L., , Song, F., , Cui, J., , & Peng, X., (2018). A near-infrared heptamethine aminocyanine dye with a long-lived excited triplet state for photodynamic therapy. Chemical communications (Cambridge, England), 54(66), 9198–9201.
[7] Choi, P. J., Park, T. I. H., Cooper, E., Dragunow, M., Denny, W. A., & Jose, J. (2020). Heptamethine Cyanine Dye Mediated Drug Delivery: Hype or Hope. Bioconjugate chemistry, 31(7), 1724–1739.
| Cas No. | 162411-29-2 | SDF | |
| Canonical SMILES | CC1(C)C(/C=C/C2=C(Cl)/C(CCC2)=C/C=C3N(CC)C4=C(C5=CC=CC=C5C=C4)C/3(C)C)=[N+](CC)C6=C1C7=CC=CC=C7C=C6.[I-] | ||
| Formula | C42H44ClIN2 | M.Wt | 739.17 |
| 溶解度 | DMSO : 50 mg/mL (67.64 mM; Need ultrasonic) | Storage | Store at -20°C, sealed, away from moisture and light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.3529 mL | 6.7643 mL | 13.5287 mL |
| 5 mM | 270.6 μL | 1.3529 mL | 2.7057 mL |
| 10 mM | 135.3 μL | 676.4 μL | 1.3529 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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