ICI 211965 (ZM-211965) (Synonyms: ZM-211965) |
| カタログ番号GC31947 |
ICI 211965 (ZM-211965) (ZM-211965) は、選択的かつ経口的に強力な 5-リポキシゲナーゼ (5-LPO) 阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 129424-08-4
Sample solution is provided at 25 µL, 10mM.
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ICI 211965 is a selective and orally potent 5-Lipoxygenase (5-LPO) inhibitor.
ICI 211965 is a selective and orally potent 5-Lipoxygenase (5-LPO) inhibitor. ICI 211965 reduces the leakage of lactate dehydrogenase (LD) and lipid peroxidation at concentrations related to its antioxidative effect and not to its 5-1ipoxygenase-inhibiting effect[1].
[1]. Crawley GC, et al. Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors. J Med Chem. 1992 Jul 10;35(14):2600-9.
Cell experiment: | The myocytes are plated on 35 mm plastic culture dishes at a density of approximately 9×105 cells/mL (1.8×106 cells/dish). The cells are kept in culture for 6 d at 37°C and 5% CO2 under aerobic conditions in a carbon dioxide incubator. During this period the cells are beating spontaneously at an approximate frequency of 20 to 40 beats/min. Each culture dish contains 0.9+0.2 mg protein. The antioxidant ICI 211965 is added to the culture medium at a final concentration of 0.1% ethanol. Cell damage is determined by leakage of lactate dehydrogenase (LD) to the medium, and is analyzed after 0.5, 1.0, 2.0, 3.0, and 5.0 h[1]. |
References: [1]. Crawley GC, et al. Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors. J Med Chem. 1992 Jul 10;35(14):2600-9. | |
| Cas No. | 129424-08-4 | SDF | |
| 同義語 | ZM-211965 | ||
| Canonical SMILES | CCC(C1=NC=CS1)(OC)C2=CC=CC(OCC3=CC=C4C=CC=CC4=C3)=C2 | ||
| Formula | C24H23NO2S | M.Wt | 389.51 |
| 溶解度 | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.5673 mL | 12.8366 mL | 25.6733 mL |
| 5 mM | 0.5135 mL | 2.5673 mL | 5.1347 mL |
| 10 mM | 0.2567 mL | 1.2837 mL | 2.5673 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
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