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Ipamorelin (acetate) (Synonyms: Aib-His-D-2-Nal-D-Phe-Lys-NH2; NNC 26-0161)

カタログ番号GC91449

イパモレリンは、ペンタペプチド成長ホルモン分泌促進剤(GHS)およびGHS受容体1a(GHS-R1a)アゴニストです。

Products are for research use only. Not for human use. We do not sell to patients.

Ipamorelin (acetate) 化学構造

サイズ 価格 在庫数 個数
5mg
$94.00
在庫あり
10mg
$122.00
在庫あり
25mg
$279.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Description of Ipamorelin (acetate)

Ipamorelin is a pentapeptide growth hormone secretagogue (GHS) and GHS receptor 1a (GHS-R1a) agonist.1,2 It binds to COS-7 cells expressing GHS-R1a (Ki = 63.4 nM), induces inositol-1,4,5-triphosphate (IP3) accumulation in BHK cells expressing GHS-R1a (EC50 = 46.9 nM), and induces GH release in primary rat pituitary cells (EC50 = 1.3 nM).1 Ipamorelin increases plasma levels of GH in rats and pigs (ED50s = 80 and 2.3 nmol/kg, respectively) but does not increase plasma levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, or thyroid stimulating hormone (TSH) in pigs when administered at a dose of 420 nmol/kg.2 It increases gastric emptying in a rat model of postoperative ileus induced by laparotomy and intestinal manipulation when administered at doses of 0.014 or 0.14 µmol/kg.3 Ipamorelin (18-450 µg/animal) increases body weight and longitudinal bone growth in rats.4

Chemical Properties of Ipamorelin (acetate)

Cas No. SDF
同義語 Aib-His-D-2-Nal-D-Phe-Lys-NH2; NNC 26-0161
Formula C38H49N9O5 ? XC2H4O2 M.Wt 711.9
溶解度 DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Ipamorelin (acetate)

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.4047 mL 7.0235 mL 14.0469 mL
5 mM 0.2809 mL 1.4047 mL 2.8094 mL
10 mM 0.1405 mL 0.7023 mL 1.4047 mL
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**ストックソリューションを準備する際には、常にバイアルラベルおよび MSDS/CoA(オンラインで利用可能)で掲載された製品のロット固有分子量を使用してください。

計算

In vivo Formulation Calculator (Clear solution) of Ipamorelin (acetate)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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