JWH 180 |
| カタログ番号GC18669 |
JWH 180は、中枢のCB1受容体（Ki = 26 nM）と末梢のCB2受容体（Ki = 9.6 nM）の両方に結合する強力な合成カンナビノイド（CB）です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 824959-87-7
Sample solution is provided at 25 µL, 10mM.
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JWH 180 is a potent synthetic cannabinoid (CB) that binds both the central CB1 receptor (Ki = 26 nM) and the peripheral CB2 receptor (Ki = 9.6 nM).[1] The physiological and toxicological properties of JWH 180 have not been characterized. Compounds like JWH 180 have been detected in herbal blends sold as recreational drugs.[2] [3][4] his product is intended for research and forensic applications.
Reference:
[1]. Huffman, J.W., Zengin, G., Wu, M.J., et al. Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: Steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists. Bioorg. Med. Chem. 13, 89-112 (2005).
[2]. Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y. Survey of current trends in the abuse of psychotropic substances and plants in Japan. Leg. Med. (Tokyo) 13(3), 109-115 (2011).
[3]. Ernst, L., Schiebel, H.M., Theuring, C., et al. Identification and characterization of JWH-122 used as new ingredient in "spice-like" herbal incenses. Forensic Science International 208(1-3), e31-35 (2011).
[4]. Uchiyama, N., Kikura-Hanajiri, R., Ogata, J., et al. Chemical analysis of synthetic cannabinoids as designer drugs in herbal products. Forensic Science International 198, 31-38 (2010).
| Cas No. | 824959-87-7 | SDF | |
| Chemical Name | (1-propyl-1H-indol-3-yl)(4-propyl-1-naphthalenyl)-methanone | ||
| Canonical SMILES | O=C(C1=CC=C(CCC)C2=C1C=CC=C2)C3=CN(CCC)C4=C3C=CC=C4 | ||
| Formula | C25H25NO | M.Wt | 355.5 |
| 溶解度 | 5mg/ml in DMSO, 20mg/mL in DMF | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.8129 mL | 14.0647 mL | 28.1294 mL |
| 5 mM | 0.5626 mL | 2.8129 mL | 5.6259 mL |
| 10 mM | 0.2813 mL | 1.4065 mL | 2.8129 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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