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Mitoquinol

カタログ番号GC44205

ミトキノールは、カチオンのトリフェニルホスフオニウムの共有結合による、特定のミトコンドリア内蓄積を示すユビキノン誘導体です。

Products are for research use only. Not for human use. We do not sell to patients.

Mitoquinol 化学構造

Cas No.: 845959-55-9

サイズ 価格 在庫数 個数
1mg
$43.00
在庫あり
5mg
$161.00
在庫あり
10mg
$214.00
在庫あり
25mg
$428.00
在庫あり

Tel:(909) 407-4943 Email: sales@glpbio.com

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Product Documents

Quality Control & SDS

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Background

ミトキノールは、カチオンのトリフェニルホスフィニウムの共有結合による特異的なミトコンドリア蓄積を示す尿素誘導体である。[1] 抗酸化作用があり、脂質過酸化による細胞死を防止し、ミトコンドリアを酸化ダメージから保護します。[2]

References:

[1]. Kelso, G.F., Porteous, C.M., Coulter, C.V., et al. Selective targeting of a redox-active ubiquinone to mitochondria within cells. Antioxidant and antiapoptotic properties. J. Biol. Chem. 276(7), 4588-4596 (2001).
[2]. O'Malley, Y., Fink, B.D., Ross, N.C., et al. Reactive oxygen and targeted antioxidant administration in endothelial cell mitochondria. J. Biol. Chem. 281(52), 39766-39775 (2006).

Chemical Properties

Cas No. 845959-55-9 SDF
Chemical Name [10-(2,5-dihydroxy-3,4-dimethoxy-6-methylphenyl)decyl]triphenyl-phosphonium, monomethanesulfonate
Canonical SMILES OC1=C(CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C(C)=C(O)C(OC)=C1OC.O=S(C)([O-])=O
Formula C37H46O4P•CH3O3S M.Wt 680.8
溶解度 DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 0.3 mg/ml Storage Store at -20°C; protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.4689 mL 7.3443 mL 14.6886 mL
5 mM 0.2938 mL 1.4689 mL 2.9377 mL
10 mM 0.1469 mL 0.7344 mL 1.4689 mL
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

レビュー

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Average Rating: 5 ★★★★★ (Based on Reviews and 39 reference(s) in Google Scholar.)

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