MM-206 |
| カタログ番号GC44227 |
STAT3 活性阻害剤である MM-206 は、STAT3 SH2 ドメイン-リン酸化ペプチド相互作用を 1.2 μM の IC50 で強力に阻害します。 MM-206 は、急性骨髄性白血病 (AML) 細胞株における用量依存的なアポトーシス誘導を示します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1809581-87-0
Sample solution is provided at 25 µL, 10mM.
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MM-206 is an inhibitor of STAT3 (IC50 = 1.16 µM in an SPR-based competitive assay). It inhibits STAT3 phosphorylation induced by granulocyte colony-stimulating factor (G-CSF) in HL-60, Kasumi-1, and MOLM-13 acute myeloid leukemia (AML) cells (IC50s = 0.8, 1.9, and 1.1 µM, respectively). MM-206 induces apoptosis more potently in AML cell lines and patient-derived primary AML tumor cells than in acute lymphoblastic leukemia cells, which do not have upregulated STAT3 activity. It also slows disease progression and improves survival in an AML mouse xenograft model when administered at a dose of 30 mg/kg per day.
| Cas No. | 1809581-87-0 | SDF | |
| Canonical SMILES | OC(C(C=CC=C1)=C1C(NS(C2=C(F)C(F)=C(F)C(F)=C2F)(=O)=O)=C3)=C3SC4=CC=CC=C4 | ||
| Formula | C22H12F5NO3S2 | M.Wt | 497.5 |
| 溶解度 | DMF: 25 mg/ml,DMF:PBS (pH 7.2) (1:8): 0.11 mg/ml,DMSO: 16 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.0101 mL | 10.0503 mL | 20.1005 mL |
| 5 mM | 0.402 mL | 2.0101 mL | 4.0201 mL |
| 10 mM | 0.201 mL | 1.005 mL | 2.0101 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 1 reference(s) in Google Scholar.)
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