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Palmitoyl Alkyne-Coenzyme A (trifluoroacetate salt)

カタログ番号GC44547

アシル補酵素A(アシル-CoA)チオエステルは、ミトコンドリアやペルオキシソームにおけるβ-酸化によるエネルギー生産、三酸グリセリド、リン脂質、コレステロールエステルの生合成など、様々な生理学的経路で使用されます。

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Palmitoyl Alkyne-Coenzyme A (trifluoroacetate salt) 化学構造

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100μg
$167.00
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250μg
$394.00
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500μg
$749.00
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1mg
$1,329.00
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Sample solution is provided at 25 µL, 10mM.

Description of Palmitoyl Alkyne-Coenzyme A (trifluoroacetate salt)

Acyl coenzyme A (acyl-CoA) thioesters are used by a variety of physiological pathways, including energy production by β-oxidation in mitochondria and peroxisomes and the biosynthesis of triacylglycerols, phospholipids, and cholesterol esters.[1]  In addition, palmitoyl CoA serves as a substrate for palmitoylation, a post-translational protein modification in which a protein acyltransferase transfers the palmitoyl group to a free thiol on target proteins. [2] Palmitoyl alkyne-CoA is an ω-alkynylated form of palmitoyl CoA. The terminal alkyne group allows the use of click chemistry linking reactions to label or pull down compounds that interact with palmitoyl CoA or, after palmitoyl transfer, the acyl group. Specifically, palmitoyl alkyne-CoA may be useful in assessing the in vitro palmitoylation of proteins.

Reference:
[1]. Waku, K. Origins and fates of fatty acyl-CoA esters. Biochim. Biophys. Acta. 1124(2), 101-111 (1992).
[2]. Budde, C., Schoenfish, M.J., Linder, M.E., et al. Purification and characterization of recombinant protein acyltransferases. Methods: A Companion to Methods in Enzymology 40(2), 143-150 (2006).

Chemical Properties of Palmitoyl Alkyne-Coenzyme A (trifluoroacetate salt)

Cas No. SDF
Chemical Name 2,2,2-trifluoroacetic acid compound with S-(2-(3-((2R)-4-(((((((2R,3S,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)-2-hydroxy-3,3-dimethylbutanamido)propanamido)ethyl) hexadec-15-ynethioate
Canonical SMILES O=C(CCNC([C@@](O)([H])C(C)(C)COP(OP(O)(OC[C@@H]1[C@@H](OP(O)(O)=O)[C@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O1)=O)(O)=O)=O)NCCSC(CCCCCCCCCCCCCC#C)=O.FC(F)(C(O)=O)F
Formula C37H62N7O17P3S•CF3COOH M.Wt 1115.9
溶解度 10mg/mL in water Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Palmitoyl Alkyne-Coenzyme A (trifluoroacetate salt)

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1 mg 5 mg 10 mg
1 mM 0.8961 mL 4.4807 mL 8.9614 mL
5 mM 0.1792 mL 0.8961 mL 1.7923 mL
10 mM 0.0896 mL 0.4481 mL 0.8961 mL
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**ストックソリューションを準備する際には、常にバイアルラベルおよび MSDS/CoA(オンラインで利用可能)で掲載された製品のロット固有分子量を使用してください。

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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