(+)-Penbutolol ((R)-Penbutolol) (Synonyms: (R)-Penbutolol; (+)-Isopenbutolol) |
| カタログ番号GC31597 |
(+)-ペンブトロール ((R)-ペンブトロール) は、β-アドレナリン受容体拮抗薬であり、IC50 は 0.74 μM.
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Cas No.: 38363-41-6
Sample solution is provided at 25 µL, 10mM.
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(+)-Penbutolol is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM[1]. (+)-Penbutolol is an optical isomer of l-penbutolol with Na+ channel-blocking action[2].
(+)-penbutolol on the [Ca2+]i-increase induced by LPC is concentration-dependent[1].(+)-penbutolol inhibits the rounding of cells dose dependently (8±4%, 56±4% and 66±2% at the concentrations of 10-6 M, 5×10-6 M and 10-5 M, respectively)[2].
[1]. Chen M, et al. Effects of beta-adrenoceptor antagonists on Ca(2+)-overload induced by lysophosphatidylcholine in rat isolated cardiomyocytes. Br J Pharmacol. 1996 Jun;118(4):865-70. [2]. Hashizume H, et al. Effects of antiischemic drugs on veratridine-induced hypercontracture in rat cardiac myocytes. Eur J Pharmacol. 1994 Dec 12;271(1):1-8.
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