Quinolinic acid (Synonyms: NSC 13127, NSC 18836, NSC 403247) |
| カタログ番号GC14547 |
キノリン酸は、キヌレニン経路を介して L-トリプトファンから合成される内因性 N-メチル-D-アスパラギン酸 (NMDA) 受容体アゴニストであり、それによって N-メチル-D-アスパラギン酸ニューロンの損傷と機能障害を媒介する可能性があります .
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Cas No.: 89-00-9
Sample solution is provided at 25 µL, 10mM.
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Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction[1][2].
Quinolinic acid (0-50 mM; 24 hours) decreases the percentage of survival cells ranging from 100±0.01% at 5 mM to 45.23±0.01% at 50 mM in N18D3 cells[2].
References:
[1]. Heyes MP, et al. Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. Brain. 1992 Oct;115 ( Pt 5):1249-73.
[2]. Jang S, et al. Neuroprotective effects of (-)-epigallocatechin-3-gallate against quinolinic acid-induced excitotoxicity via PI3K pathway and NO inhibition. Brain Res. 2010 Feb 8;1313:25-33.
| Cas No. | 89-00-9 | SDF | |
| 同義語 | NSC 13127, NSC 18836, NSC 403247 | ||
| Chemical Name | pyridine-2,3-dicarboxylic acid | ||
| Canonical SMILES | OC(C1=CC=CN=C1C(O)=O)=O | ||
| Formula | C7H5NO4 | M.Wt | 167.12 |
| 溶解度 | ≥ 7.8mg/mL in DMSO | Storage | Store at RT |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 5.9837 mL | 29.9186 mL | 59.8372 mL |
| 5 mM | 1.1967 mL | 5.9837 mL | 11.9674 mL |
| 10 mM | 0.5984 mL | 2.9919 mL | 5.9837 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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