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(R)-Elexacaftor (Synonyms: (R)-VX-445)

カタログ番号GC69812

(R)-Elexacaftorは、特許WO2018107100A1の化合物37から得られるElexacaftor(化合物1)のエナンチオマーです。 (R)-Elexacaftorは、システム性線維症膜貫通型電気伝導調節因子(CFTR)修正剤であり、CFTR dF508に対するEC50値は0.29μMです。

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(R)-Elexacaftor 化学構造

Cas No.: 2229860-99-3

サイズ 価格 在庫数 個数
10mM (in 1mL DMSO)
$296.00
在庫あり
1mg
$99.00
在庫あり
5mg
$225.00
在庫あり
10mg
$360.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Chemical Properties of (R)-Elexacaftor

Cas No. 2229860-99-3 SDF
同義語 (R)-VX-445
Formula C26H34F3N7O4S M.Wt 597.65
溶解度 DMSO : 125 mg/mL (209.15 mM; Need ultrasonic) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of (R)-Elexacaftor

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.6732 mL 8.3661 mL 16.7322 mL
5 mM 0.3346 mL 1.6732 mL 3.3464 mL
10 mM 0.1673 mL 0.8366 mL 1.6732 mL
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計算

In vivo Formulation Calculator (Clear solution) of (R)-Elexacaftor

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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