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(R)-GSK-3685032

カタログ番号GC64210

(R)-GSK-3685032 は、GSK-3685032 の R-エナンチオマーです。 GSK-3685032 は、0.036 μM の IC50 を持つ、非時間依存性、非共有結合性、ファーストインクラスの可逆的 DNMT1 選択的阻害剤です。 GSK-3685032 は、DNA メチル化の強力な損失、転写活性化、およびがん細胞増殖阻害を誘導します。

Products are for research use only. Not for human use. We do not sell to patients.

(R)-GSK-3685032 化学構造

Cas No.: 2170140-50-6

サイズ 価格 在庫数 個数
5 mg
$450.00
在庫あり
10 mg
$765.00
在庫あり

Tel:(909) 407-4943 Email: sales@glpbio.com

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition[1][2].

[1]. Adams, Nicholas David, et al. Substituted pyridines as inhibitors of DNMT1 and their preparation. WO2017216727A1.
[2]. Pappalardi MB, et al. Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer. 2021;2(10):1002-1017.

Chemical Properties

Cas No. 2170140-50-6 SDF Download SDF
Formula C22H24N6OS M.Wt 420.53
溶解度 DMSO : 60 mg/mL (142.68 mM; Need ultrasonic) Storage 4°C, away from moisture and light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.378 mL 11.8898 mL 23.7795 mL
5 mM 0.4756 mL 2.378 mL 4.7559 mL
10 mM 0.2378 mL 1.189 mL 2.378 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Average Rating: 5 ★★★★★ (Based on Reviews and 32 reference(s) in Google Scholar.)

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