(R,S)-Anatabine (Synonyms: (±)-Anatabine) |
| カタログ番号GC16032 |
(R,S)-アナタビンは、ナス科の植物に見られるマイナーなタバコ アルカロイドで、タバコの使用を検出するための特定のマーカーとして使用できます 。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2743-90-0
Sample solution is provided at 25 µL, 10mM.
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Anatabine, an alkaloid with a chemical structural similarity to nicotine, is a minor tobacco alkaloid produced in plants of the Solanacea family including tobacco, green tomatoes, peppers and eggplants [1]. (R,S)-Anatabine is an Aβ inhibitor [1].
Aβ peptides play a dominant role in the development of Alzheimer's disease. Natural soluble Aβ oligomers and more specifically Aβ dimers isolated from Alzheimer's disease brains have been involved in inducing tau hyperphosphorylation and neuritic degeneration, which results in the accumulation of Aβ oligomers to the neurofibrillary degeneration observed in Alzheimer's disease [1].
In vitro: Anatabine dose-dependently lowered Aβ1-40 and Aβ1-42 levels and reduced sAPPβ production without any effects on sAPPα levels. Anatabine lowered Aβ production by mainly impacting the β-cleavage of APP. Anatabine lowered NFκB activation. Anatabine inhibited BACE-1 transcription and reduced BACE-1 protein levels in human neuronal like SHSY-5Y cells. (R,S)-Anatabine also dose dependently inhibits NF-κB activation [1].
In vivo: In a transgenic mouse model of Alzheimer's disease, acute treatment with anatabine for 4 days significantly lowered brain soluble Aβ1-40 and Aβ1-42 levels [1].
Reference:
[1] Paris D, Beaulieu-Abdelahad D, Bachmeier C, et al. Anatabine lowers Alzheimer's Aβ production in vitro and in vivo[J]. European journal of pharmacology, 2011, 670(2): 384-391.
| Cas No. | 2743-90-0 | SDF | |
| 同義語 | (±)-Anatabine | ||
| Chemical Name | 1,2,3,6-tetrahydro-2,3'-bipyridine | ||
| Canonical SMILES | [C@@H]1(C2=CN=CC=C2)CC=CCN1 | ||
| Formula | C10H12N2 | M.Wt | 160.2 |
| 溶解度 | ≤15mg/ml in DMSO;15mg/ml in dimethyl formamide | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 6.2422 mL | 31.211 mL | 62.422 mL |
| 5 mM | 1.2484 mL | 6.2422 mL | 12.4844 mL |
| 10 mM | 0.6242 mL | 3.1211 mL | 6.2422 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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