(R)-Trolox |
| カタログ番号GC38720 |
(R)-Trolox はビタミン E 類似体であり、Ki 値 0.83 mM、ID50 値 1.88 mM の競合的チロシナーゼ阻害剤です。 (R)-トロロックスは、(S) エナンチオマーよりも強いチロシナーゼ親和性を持っています (Ki 値 0.61 mM)。
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Cas No.: 53101-49-8
Sample solution is provided at 25 µL, 10mM.
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(R)-Trolox is a water soluble vitamin E analogue and a competitive tyrosinase inhibitor with a Ki value of 0.83 mM and a ID50 value of 1.88 mM[1]. The (R)-Trolox has stronger tyrosinase affinity than the (S) enantiomer (Ki value of 0.61 mM)[1].
As compared to the control containing no inhibitor, DMSO suppresses the tyrosinase activity at tested levels, 100 and 200 µL in a total volume of 3.0 mL. The inhibition of DMSO on the mushroom tyrosinase is dosedependent. Additions of DMSO at the two levels in the tyrosinase digests containing (R)-Trolox ((R)-HTCCA) results in further inhibitions of the tyrosinase activity. The influence of the DMSO on the inhibitory effects of (R)-Trolox against the tyrosinase is also dose-dependent[1].
[1]. Yu L. Inhibitory effects of (S)- and (R)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acids on tyrosinase activity. J Agric Food Chem. 2003 Apr 9;51(8):2344-7.
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