Ras Inhibitory Peptide (Synonyms: Sos SH3 Domain Inhibitor) |
| カタログ番号GC44806 |
セブンレスホモログ1（Sos1）は、成長因子受容体結合タンパク質2（Grb2）のSH3ドメインに結合してRas-GDPからRas-GTPへの交換を指示し、ERKの活性化を引き起こすグアニン核otide交換因子（GEF）です。
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Cas No.: 159088-48-9
Sample solution is provided at 25 µL, 10mM.
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Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2. It specifically blocks the interaction of the GEF with Grb2, preventing an interaction that is essential for Ras activation by receptor tyrosine kinases, including epidermal growth factor receptor.
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