ホーム >> Signaling Pathways >> Membrane Transporter/Ion Channel >> VDAC

VDAC

Voltage-dependent anion channels (VDACs) are a class of porin ion channel located on the outer mitochondrial membrane. This major protein of the outer mitochondrial membrane of eukaryotes forms a voltage-dependent anion-selective channel (VDAC) that behaves as a general diffusion pore for small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane. Additionally, VDAC is an important regulator of Ca2+ transport in and out of the mitochondria.

製品は  VDAC

  1. Cat.No. 商品名 インフォメーション
  2. GC61141 NSC 15364 NSC 15364 は、VDAC1 のオリゴマー化とアポトーシスの阻害剤です 。 NSC 15364  Chemical Structure
  3. GC62641 WEHI-9625 WEHI-9625 は、EC50 が 69 nM のクラス初のアポトーシス阻害剤である三環式スルホンです。 WEHI-9625 は VDAC2 に結合し、マウス BAK によって駆動されるアポトーシスを阻害する能力を促進します。 WEHI-9625 は、ヒト BAK と密接に関連するアポトーシス エフェクター BAX の両方に対して完全に不活性です。 WEHI-9625  Chemical Structure

2 アイテム

降順