Calpains
Calpains (calcium-dependent papain-like enzymes) are a family of intracellular enzymes that consist of complex multi-domains and share a calcium-dependent cysteine protease core. With the development of human genome sequencing, a total of fifteen human calpain genes have been identified (CAPN1 to CAPN15). Calpain 1 (μ-calpain) and calpain 2 (m-calpain) are the two most abundant and well studied members of calpain family in mammals, which are heterodimers characterized by consisting of an isoform-specific large subunit (approximately 80 kDa) and a common small subunit (approximately 28 kDa). The large subunit consists of four domains, domain I (function not clear), domain II (cysteine protease domain), domain III (function not clear) and domain IV (Ca2+-binding domain); while the small subunit consists of two domains, domain V (N-terminal glycine-clustering hydrophobic region) and domain VI (C-terminal Ca2+-binding domain).
製品は Calpains
- Cat.No. 商品名 インフォメーション
- GC12152 Acetyl-Calpastatin (184-210) (human)
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GC12527
Calpain Inhibitor I, ALLN
非選択的システインプロテアーゼ阻害剤
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GC16383
Calpain Inhibitor II, ALLM
カルパイン阻害剤
- GC12479 Calpain Inhibitor XII カルパイン阻害剤 XII は、カルパイン I の可逆的かつ選択的な阻害剤です (μ-カルパイン、Ki=19 nM)。
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GC10342
Calpeptin
カルパイン阻害剤
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GC13418
E-64
多様な生物学的活性を持つ真菌代謝産物
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GC11640
MDL 28170
細胞浸透性の高く、選択的なカルパイン阻害剤
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GC10383
MG-132
強力なプロテアソーム阻害剤
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GC13450
PD 145305
カルパインの選択的阻害剤
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GC16912
PD 150606
カルパインの阻害剤
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GC15066
Z-FA-FMK
システインプロテアーゼの阻害剤、カテプシンBを含む。