Rosabulin (STA 5312) |
| カタログ番号GC33169 |
ロザブリン (STA 5312) (STA 5312) は、微小管の集合を阻害する強力な経口活性微小管阻害剤です。ロザブリン (STA 5312) には、広範囲の抗腫瘍活性があります。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 501948-05-6
Sample solution is provided at 25 µL, 10mM.
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Rosabulin is a potent microtubule inhibitor, with anti-cancer activities.
Rosabulin demonstrates substantial anti-proliferative activity against a wide range of cancer cell linesin vitro, with IC50 values extending down into the nanomolar range. Rosabulin is inhibition of microtubule assembly and subsequent arrest of the cell cycle. Rosabulin is active against several tumor cell lines that express moderate to high levels of P-glycoprotein (Pgp), including lines insensitive to Taxol, Vincristine, and Adriamycin in which Pgp activity is a major contributor to the MDR phenotype[1].
Rosabulin has shown in vivo activity in several murine tumors as well as human tumor xenograft models, including drug resistant tumors[1].
[1]. Keizo Koya, et al. STA-5312, a novel tubulin inhibitor, demonstrates the anti-cancer activity against chemotherapy-resistant cancers. Proc Amer Assoc Cancer Res, Volume 45, 2004
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