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(S)-Bromoenol lactone (Synonyms: (S)BEL)

カタログ番号GC40679

(S)-ブロモエノール ラクトン ((S)-BEL) は、カルシウム非依存性ホスホリパーゼ A2β (iPLA2β) の不可逆的キラル機構ベースの阻害剤であり、培養ラット大動脈平滑筋 (A10) からのバソプレシン誘発性アラキドン酸放出を阻害します。 IC50 が 2 μM の細胞。

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(S)-Bromoenol lactone 化学構造

Cas No.: 478288-94-7

サイズ 価格 在庫数 個数
500μg
$43.00
在庫あり
1mg
$77.00
在庫あり
5mg
$321.00
在庫あり
10mg
$514.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 value of 2 µM. (S)-BEL is more than 1,000-fold selective for iPLA2 versus cPLA2, and is 10-fold selective for iPLA2β versus iPLA2γ.

Chemical Properties

Cas No. 478288-94-7 SDF
同義語 (S)BEL
Canonical SMILES Br/C=C1\CC[C@H](C(=O)O\1)c1cccc2ccccc12
Formula C16H13BrO2 M.Wt 317.2
溶解度 DMF: 50 mg/ml,DMSO: 25 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): .05 mg/ml Storage Store at -20°C, protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.1526 mL 15.7629 mL 31.5259 mL
5 mM 0.6305 mL 3.1526 mL 6.3052 mL
10 mM 0.3153 mL 1.5763 mL 3.1526 mL
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