(S)-Canadine (Synonyms: (-)-Canadine, (S)-Tetrahydroberberine) |
| カタログ番号GC48719 |
(S)-カナジンはアルカロイドであり、殺虫活性を持つベルベリンの生合成における中間体です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 5096-57-1
Sample solution is provided at 25 µL, 10mM.
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(S)-Canadine is an alkaloid and intermediate in the biosynthesis of berberine that has been found in H. canadensis and has insecticidal activity.1,2,3,4 (S)-Canadine induces mortality in D. melanogaster larvae (LC50 = 0.91 µmol/ml of diet) and adults (LD50 = 2.5 µg/insect).4
1.Malhotra, S., Taneja, S.C., and Dhar, K.L.Minor alkaloid from Coscinium fenestratumPhytochem.28(7)1998-1999(1989) 2.Galanie, S., and Smolke, C.D.Optimization of yeast-based production of medicinal protoberberine alkaloidsMicrob. Cell Fact.14144(2015) 3.Leyte-Lugo, M., Britton, E.R., Foil, D.H., et al.Secondary metabolites from the leaves of the medicinal plant goldenseal (Hydrastis canadensis)Phytochem. Lett.2054-60(2017) 4.Miyazawa, M., Yoshio, K., Ishikawa, Y., et al.Insecticidal alkaloid against Drosophila melanogaster from tubers of Corydalis bulbosaNat. Prod. Lett.8(4)299-302(1996)
| Cas No. | 5096-57-1 | SDF | |
| 同義語 | (-)-Canadine, (S)-Tetrahydroberberine | ||
| Canonical SMILES | COC1=C2CN3[C@](CC2=CC=C1OC)([H])C4=CC(OCO5)=C5C=C4CC3 | ||
| Formula | C20H21NO4 | M.Wt | 339.4 |
| 溶解度 | Chloroform: slightly soluble,Methanol: very slightly, heated | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.9464 mL | 14.7319 mL | 29.4638 mL |
| 5 mM | 0.5893 mL | 2.9464 mL | 5.8928 mL |
| 10 mM | 0.2946 mL | 1.4732 mL | 2.9464 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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