BMP signaling agonist sb4 |
| カタログ番号GC50593 |
BMP シグナル伝達アゴニスト sb4 は、74 nM の EC50 値を持つ強力なベンゾオキサゾール骨形成タンパク質 4 (BMP4) シグナル伝達アゴニストであり、細胞内 p-SMAD-1/5/9 を安定化することによって BMP シグナル伝達を活性化します。 BMP シグナル伝達アゴニスト sb4 は、BMP4 標的遺伝子（DNA 結合の阻害剤、Id1 および Id3）の標準的な BMP シグナル伝達を活性化します。
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Cas No.: 100874-08-6
Sample solution is provided at 25 µL, 10mM.
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BMP signaling agonist sb4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC50 value of 74 nM, activates BMP signaling by stabilizing intracellular p-SMAD-1/5/9. BMP signaling agonist sb4 activates BMP4 target genes (inhibitors of DNA binding, Id1 and Id3) canonical BMP signaling[1].
BMP signaling agonist sb4 (0.05 μM-1 μM; 24 hours) induces phosphorylated SMAD-1/5/9 in a dose-dependent manner in PRECs cells under serum-starved conitions[1]. BMP signaling agonist sb4 (1 μM; 0-60 mins) enhances the efficacy of signaling at each concentration of rhBMP4 tested. This effect is most pronounced at low concentrations of rhBMP4, whereby sb4 increases BRE-luc expression 2-fold at 0.4 ng/ml of rhBMP4[1].
Reference:
[1]. Bradford STJ, et al. High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds.J Biol Chem. 2019 Mar 1;294(9):3125-3136.
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