U-51605 |
| カタログ番号GC45104 |
U-51605は、エンドペルオキシドプロスタグランジンH2（PGH2）の安定したアナログです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 64192-56-9
Sample solution is provided at 25 µL, 10mM.
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U-51605 is a stable analog of the endoperoxide prostaglandin H2 (PGH2). It is an inhibitor of both prostacyclin (PGI) and thromboxane (TX) synthases with more selectivity towards PGI synthase. U-51605 is also a partial agonist at TP receptors. In human foreskin fibroblasts, U-51605 inhibits PGI synthase at a concentration of 2.8 µM, whereas, human platelet TX synthase is inhibited at a concentration of 5.6 µM. At concentrations up to 1 µM, U-51605 reduced the release of prostacyclin in SHR aorta elicited by the calcium ionophore A-23187 with no effect on TXA2 production and yet significantly increased PGE2 and PGF2α release.
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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