Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) (Synonyms: 4-Isothioureidobutyronitrile, NSC 525990) |
| Catalog No.GC32919 |
Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) is a potent activator of p53, induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells. Kevetrin a preferential cytotoxic activity against blast cells.
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Cas No.: 66592-89-0
Sample solution is provided at 25 µL, 10mM.
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Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Target:p53in vitro: Kevetrin activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Kevetrin may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. in vivo: Kevetrin has demonstrated potent anti-tumor efficacy against various carcinoma xenograft models: lung, breast, colon, prostate and squamous cell carcinoma, and in a leukemia tumor model. In drug-resistant cell lines, Kevetrin has shown excellent activity, galvanizing the Company to focus on Kevetrin's development potential in this area.
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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