>>Signaling Pathways>> Ox Stress Reagents>> Lipid Peroxidation>>1,3,7-Trimethyluric Acid

1,3,7-Trimethyluric Acid (Synonyms: 8-oxo Caffeine, NSC 11259)

Catalog No.GC41837

1,3,7-트리메틸요르산은 카페인의 대사산물입니다. 카페인에 대한 대사 비율 1,3,7-Trimethyluric Acid는 코호트에서 CYP3A 활성의 가변성을 설명하는 바이오마커로 평가될 수 있습니다.

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1,3,7-Trimethyluric Acid Chemical Structure

Cas No.: 5415-44-1

Size 가격 재고 수량
25mg
US$83.00
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50mg
US$160.00
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100mg
US$302.00
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250mg
US$672.00
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Sample solution is provided at 25 µL, 10mM.

Description of 1,3,7-Trimethyluric Acid

1,3,7-Trimethyluric acid is a methyl derivative of uric acid and a product of C-8 oxidation of caffeine by cytochrome P450 enzymes. It can be detected in urine as a marker of caffeine consumption.

Reference:
[1]. Tassaneeyakul, W., Birkett, D.J., McManus, M.E., et al. Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms. Biochem. Pharmacol. 47(10), 1767-1776 (1994).
[2]. Bhat, V.B., Sridhar, G.R., and Madyastha, K.M. Efficient scavenging of hydroxyl radicals and inhibition of lipid peroxidation by novel analogues of 1,3,7-trimethyluric acid. Life Sci. 70(4), 381-393 (2001).

Chemical Properties of 1,3,7-Trimethyluric Acid

Cas No. 5415-44-1 SDF
Synonyms 8-oxo Caffeine, NSC 11259
Chemical Name 7,9-dihydro-1,3,7-trimethyl-1H-purine-2,6,8(3H)-trione
Canonical SMILES O=C(N1)N(C)C2=C1N(C)C(N(C)C2=O)=O
Formula C8H10N4O3 M.Wt 210.2
Solubility DMF: 5 mg/ml,DMSO: 20 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 1,3,7-Trimethyluric Acid

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 4.7574 mL 23.7869 mL 47.5737 mL
5 mM 0.9515 mL 4.7574 mL 9.5147 mL
10 mM 0.4757 mL 2.3787 mL 4.7574 mL
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In vivo Formulation Calculator (Clear solution) of 1,3,7-Trimethyluric Acid

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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