>>Signaling Pathways>> Metabolism>> Carbohydrate Metabolism>>1,4-dideoxy-1,4-imino-D-Arabinitol (hydrochloride)

1,4-dideoxy-1,4-imino-D-Arabinitol (hydrochloride) (Synonyms: DAB)

Catalog No.GC41858

1,4-dideoxy-1,4-imino-D-Arabinitol (DAB) is an inhibitor of glycogen phosphorylase, a key enzyme in glycogenolysis.

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1,4-dideoxy-1,4-imino-D-Arabinitol (hydrochloride) Chemical Structure

Cas No.: 100991-92-2

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Sample solution is provided at 25 µL, 10mM.

Product Documents

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Background

1,4-dideoxy-1,4-imino-D-Arabinitol (DAB) is an inhibitor of glycogen phosphorylase, a key enzyme in glycogenolysis. It inhibits glycogenolysis in isolated liver cells (IC50 = 1.0 µM) and in homogenates of cerebral cortex and cerebellum (IC50s = 463 and 383 nM, respectively).[1][2][3] DAB is used to inhibit glycogenolysis, in liver and in brain, in various animal models.[4][5][6]

Reference:
[1]. Andersen, B., and Westergaard, N. The effect of glucose on the potency of two distinct glycogen phosphorylase inhibitors. Biochem. J. 367(Pt. 2), 443-450 (2002).
[2]. Andersen, B., Rassov, A., Westergaard, N., et al. Inhibition of glycogenolysis in primary rat hepatocytes by 1, 4-dideoxy-1,4-imino-D-arabinitol. Biochem. J. 342, 545-550 (1999).
[3]. Walls, A.B., Sickmann, H.M., Brown, A., et al. Characterization of 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) as an inhibitor of brain glycogen shunt activity. J. Neurochem. 105(4), 1462-1470 (2008).
[4]. Fosgerau, K., Westergaard, N., Quistorff, B., et al. Kinetic and functional characterization of 1,4-dideoxy-1, 4-imino-d-arabinitol: a potent inhibitor of glycogen phosphorylase with anti-hyperglyceamic effect in ob/ob mice. Arch. Biochem. Biophys. 380(2), 274-284 (2000).
[5]. Gibbs, M.E. Role of Glycogenolysis in Memory and Learning: Regulation by Noradrenaline, Serotonin and ATP. Front. Integr. Neurosci. 9:70, 70 (2016).
[6]. Marina, N., Ang, R., Machhada, A., et al. Brainstem hypoxia contributes to the development of hypertension in the spontaneously hypertensive rat. Hypertension 65(4), 775-783 (2015).

Chemical Properties

Cas No. 100991-92-2 SDF
Synonyms DAB
Chemical Name 2R-(hydroxymethyl)-3R,4R-pyrrolidinediol, monohydrochloride
Canonical SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O.Cl
Formula C5H11NO3•HCl M.Wt 169.6
Solubility 10 mg/ml in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 5.8962 mL 29.4811 mL 58.9623 mL
5 mM 1.1792 mL 5.8962 mL 11.7925 mL
10 mM 0.5896 mL 2.9481 mL 5.8962 mL
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Review for 1,4-dideoxy-1,4-imino-D-Arabinitol (hydrochloride)

Average Rating: 5 ★★★★★ (Based on Reviews and 2 reference(s) in Google Scholar.)

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