>>Signaling Pathways>> Chromatin/Epigenetics>> PARP>>1,5-Isoquinolinediol

1,5-Isoquinolinediol (Synonyms: NSC 65585)

Catalog No.GC40468

1,5-Isoquinolinediol은 IC50이 0.18-0.37 μM인 강력한 PARP 억제제입니다.

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1,5-Isoquinolinediol Chemical Structure

Cas No.: 5154/2/9

Size 가격 재고 수량
5mg
US$47.00
재고 있음
25mg
US$108.00
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100mg
US$287.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. [1] 1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50 = 0.39 μM). [2] It has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. [3][4][5] This compound can be used with cells in culture and in animals.[4][6][7]

Reference:
[1]. Davar, D., Beumer, J.H., Hamieh, L., et al. Role of PARP inhibitors in cancer biology and therapy. Current Medicinal Chemistry 19(23), 3907-3921 (2012).
[2]. Banasik, M., Komura, H., Shimoyama, M., et al. Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. The Journal of Biological Chemisty 267(3), 1569-1575 (1992).
[3]. Ruscetti, T., Lehnert, B.E., Halbrook, J., et al. Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase. The Journal of Biological Chemisty 273(23), 14461-14467 (1998).
[4]. Chatterjee, P.K., Zacharowski, K., Cuzzocrea, S., et al. Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivo. The FASEB Journal 14(5), 641-651 (2000).
[5]. Bowes, J., McDonald, M.C., Piper, J., et al. Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress. Cardiovascular Research 41(1), 126-134 (1999).
[6]. Byun, J.Y., Kim, M.J., Eum, D.Y., et al. Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells. Molecular Pharmacology 76(4), 734-744 (2009).
[7]. Kang, Y.H., Yi, M.J., Kim, M.J., et al. Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: Reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondria. Cancer Research 64(24), 8960-8967 (2004).

Chemical Properties

Cas No. 5154/2/9 SDF
Synonyms NSC 65585
Chemical Name 5-hydroxy-1(2H)-isoquinolinone
Canonical SMILES OC1=C2C(C(NC=C2)=O)=CC=C1
Formula C9H7NO2 M.Wt 161.2
Solubility Soluble in DMSO and methanol, insoluble in water Storage Store at 4°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 6.2035 mL 31.0174 mL 62.0347 mL
5 mM 1.2407 mL 6.2035 mL 12.4069 mL
10 mM 0.6203 mL 3.1017 mL 6.2035 mL
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Review for 1,5-Isoquinolinediol

Average Rating: 5 ★★★★★ (Based on Reviews and 39 reference(s) in Google Scholar.)

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