>>Signaling Pathways>> Others>>1-Acetyl-3-o-toluyl-5-fluorouracil (A-OT-Fu)

1-Acetyl-3-o-toluyl-5-fluorouracil (A-OT-Fu) (Synonyms: A-?OT-?Fu)

Catalog No.GC34189

1-아세틸-3-o-톨루일-5-플루오로우라실(A-OT-Fu)은 강력한 항종양제입니다.

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1-Acetyl-3-o-toluyl-5-fluorouracil (A-OT-Fu) Chemical Structure

Cas No.: 71861-76-2

Size 가격 재고 수량
1mg
US$184.00
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5mg
US$368.00
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10mg
US$625.00
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20mg
US$1,103.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Protocol

Animal experiment:

Mice: Of the ten groups of tumor bearing mice, subcutaneous administration of 5-fluorouracil or 1-Acetyl-3-o-toluyl-5-fluorouracil is made at a dose of 0.2, 0.4 and 0.6 mmol/kg/d on six groups in the buttock region. In three groups, oil solution of 1-Acetyl-3-o-toluyl-5-fluorouracil is administered orally with a stomach tube at a dose of 0.2, 0.4 and 0.6 mmol/kg/d. The remaining group is used as tumor bearing control. During the period of the experiment, body weight is measured every 3 day and the long and short diameters of the tumor are measured daily[1].

References:

[1]. Yata N, et al. Anti-tumor activity of 1-acetyl-3-o-toluyl-5-fluorouracil against murine hepatoma MH134 and its effects on tissue weights following subcutaneous and oral administration. J Pharmacobiodyn. 1985 Apr;8(4):264-9.

Background

1-Acetyl-3-o-toluyl-5-fluorouracil is a potent an antineoplastic agent.

Oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil demonstrates a remarkable effect on MH134 solid tumors, the effect being more marked than that of subcutaneous administration of 1-Acetyl-3-o-toluyl-5-fluorouracil. Anti-tumor activity of oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at a dose of 0.2 mmol/kg/d is comparable to that of subcutaneous administration of 5-fluorouracil at the same dose. The level of decrease in thymus weight and the magnitude of increase of spleen weight following oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at any dose are smaller than those by subcutaneous administration of 5-fluorouracil (0.2 mmol/kg/d)[1].

[1]. Yata N, et al. Anti-tumor activity of 1-acetyl-3-o-toluyl-5-fluorouracil against murine hepatoma MH134 and its effects on tissue weights following subcutaneous and oral administration. J Pharmacobiodyn. 1985 Apr;8(4):264-9.

Chemical Properties

Cas No. 71861-76-2 SDF
Synonyms A-?OT-?Fu
Canonical SMILES O=C1N(C(C2=CC=CC=C2C)=O)C(C(F)=CN1C(C)=O)=O
Formula C14H11FN2O4 M.Wt 290.25
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.4453 mL 17.2265 mL 34.4531 mL
5 mM 0.6891 mL 3.4453 mL 6.8906 mL
10 mM 0.3445 mL 1.7227 mL 3.4453 mL
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Review for 1-Acetyl-3-o-toluyl-5-fluorouracil (A-OT-Fu)

Average Rating: 5 ★★★★★ (Based on Reviews and 4 reference(s) in Google Scholar.)

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