>>Lipids>> Prostaglandins>>1-O-Hexadecyl-sn-glycerol

1-O-Hexadecyl-sn-glycerol (Synonyms: α-Chimyl Alcohol, (S)-(+)-Chimyl Alcohol)

Catalog No.GC18235

1-O-Hexadecyl-sn-glycerol is a bioactive alkyl glyceryl ether.

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1-O-Hexadecyl-sn-glycerol Chemical Structure

Cas No.: 506-03-6

Size 가격 재고 수량
100mg
US$112.00
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250mg
US$183.00
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500mg
US$335.00
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1g
US$503.00
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Sample solution is provided at 25 µL, 10mM.

Description of 1-O-Hexadecyl-sn-glycerol

1-O-Hexadecyl-sn-glycerol is a bioactive alkyl glyceryl ether. It reduces UVB-induced cell death and production of reactive oxygen species (ROS) and prostaglandin E2 in normal human epidermal keratinocytes (NHEKs). 1-O-Hexadecyl-sn-glycerol (50 μM) increases coronary flow and left ventricular developed pressure and reduces malondialdehyde (MDA) formation ex vivo in a rat heart model of ischemia/reperfusion injury.

References:
[1].Yokota, M., Yahagi, S., Tokudome, Y., et al. Chimyl alcohol suppresses PGE2 synthesis by human epidermal keratinocytes through the activation of PPAR-γ J. Oleo. Sci. 67(4), 455-462 (2018).

[2].Maulik, N., Tosaki, A., Engelman, R.M., et al. Myocardial salvage by chimyl alcohol: Possible role of peroxisomal dysfunction in reperfusion injury Ann. N.Y. Acad. Sci. 723(1), 380-384 (1994).

Chemical Properties of 1-O-Hexadecyl-sn-glycerol

Cas No. 506-03-6 SDF
Synonyms α-Chimyl Alcohol, (S)-(+)-Chimyl Alcohol
Chemical Name 3-(hexadecyloxy)-1,2S-propanediol
Canonical SMILES CCCCCCCCCCCCCCCCOC[C@@H](O)CO
Formula C19H40O3 M.Wt 316.5
Solubility 0.16 mg/ml in DMSO, 16 mg/ml in DMF, 5 mg/ml Ethanol Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 1-O-Hexadecyl-sn-glycerol

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1 mg 5 mg 10 mg
1 mM 3.1596 mL 15.7978 mL 31.5956 mL
5 mM 0.6319 mL 3.1596 mL 6.3191 mL
10 mM 0.316 mL 1.5798 mL 3.1596 mL
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In vivo Formulation Calculator (Clear solution) of 1-O-Hexadecyl-sn-glycerol

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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