1-Oleoyl Lysophosphatidic Acid (Synonyms: 1-Oleoyl LPA, Oleoyl-sn-3-Glycerophosphate) |
Catalog No.GC42011 |
강력한 LPA 수용체 작용제
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 65528-98-5
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
1-올레오일 리소인산은 sn-1 위치에 오레산을 함유하는 리소인산(LPA)의 일종입니다. 인산화지방은 직접 인지포리데이스 D(PLD)의 작용을 통해 또는 인지포리데이스 C(PLC)에 의한 이원 과정을 거쳐 다이아실글리세롤(DAG) 해방 후 디글리세롤 키나제에 의한 DAG의 인산화로 생성됩니다.[1] sn-2 위치에서 지방산의 가수분해는 인지포리파제 A2 (PLA2)에 의해 생체활성 LPA를 생성합니다. LPA는 다섯 가지 서로 다른 G 단백질 연결 수용체 중 하나에 결합하여 세포 증식, 매끄러운 근육 수축, 혈소판 집적, 신경돌출 철회 및 세포 운동 등 다양한 생물학적 반응을 조절합니다.[2],[1] 1-Oleoyl lysophosphatidic acid은 A431 세포에서 칼슘 동원과 여러 종류의 세포주에서 생장 자극으로서 LPA 아날로그 중 가장 강력합니다.[3],[4]
References:
[1]. Moolenaar, W.H. LPA: A novel lipid mediator with diverse biological actions. Trends in Cell Biology 4, 213-219 (1994).
[2]. Noguchi, K., Ishii, S., and Shimizu, T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. The Journal of Biological Chemisty 278(28), 25600-25606 (2003).
[3]. Jalink, K., Hengeveld, T., Mulder, S., et al. Lysophosphatidic acid-induced Ca2+ mobilization in human A4431 cells: Structure-activity analysis. Biochemistry Journal 307, 609-616 (1995).
[4]. van Corven, E.J., van Rijswijk, A., Jalink, K., et al. Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin. Biochemistry Journal 281, 163-169 (1992).
Cas No. | 65528-98-5 | SDF | |
Synonyms | 1-Oleoyl LPA, Oleoyl-sn-3-Glycerophosphate | ||
Chemical Name | 1-O-9Z-octadecenoyl-sn-glyceryl-3-phosphoric acid | ||
Canonical SMILES | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O | ||
Formula | C21H41O7P | M.Wt | 436.5 |
Solubility | DMF: 2 mg/ml; DMSO: 2.5 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): 3 mg/ml | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 2.291 mL | 11.4548 mL | 22.9095 mL |
5 mM | 0.4582 mL | 2.291 mL | 4.5819 mL |
10 mM | 0.2291 mL | 1.1455 mL | 2.291 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
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