>>Signaling Pathways>> GPCR/G protein>> LPL Receptor>>1-Oleoyl Lysophosphatidic Acid

1-Oleoyl Lysophosphatidic Acid (Synonyms: 1-Oleoyl LPA, Oleoyl-sn-3-Glycerophosphate)

Catalog No.GC42011

강력한 LPA 수용체 작용제

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1-Oleoyl Lysophosphatidic Acid Chemical Structure

Cas No.: 65528-98-5

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1mg
US$36.00
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5mg
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10mg
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25mg
US$496.00
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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 2 publications

Product Documents

Quality Control & SDS

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Background

1-올레오일 리소인산은 sn-1 위치에 오레산을 함유하는 리소인산(LPA)의 일종입니다. 인산화지방은 직접 인지포리데이스 D(PLD)의 작용을 통해 또는 인지포리데이스 C(PLC)에 의한 이원 과정을 거쳐 다이아실글리세롤(DAG) 해방 후 디글리세롤 키나제에 의한 DAG의 인산화로 생성됩니다.[1] sn-2 위치에서 지방산의 가수분해는 인지포리파제 A2 (PLA2)에 의해 생체활성 LPA를 생성합니다. LPA는 다섯 가지 서로 다른 G 단백질 연결 수용체 중 하나에 결합하여 세포 증식, 매끄러운 근육 수축, 혈소판 집적, 신경돌출 철회 및 세포 운동 등 다양한 생물학적 반응을 조절합니다.[2],[1] 1-Oleoyl lysophosphatidic acid은 A431 세포에서 칼슘 동원과 여러 종류의 세포주에서 생장 자극으로서 LPA 아날로그 중 가장 강력합니다.[3],[4]

References:

[1]. Moolenaar, W.H. LPA: A novel lipid mediator with diverse biological actions. Trends in Cell Biology 4, 213-219 (1994).
[2]. Noguchi, K., Ishii, S., and Shimizu, T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. The Journal of Biological Chemisty 278(28), 25600-25606 (2003).
[3]. Jalink, K., Hengeveld, T., Mulder, S., et al. Lysophosphatidic acid-induced Ca2+ mobilization in human A4431 cells: Structure-activity analysis. Biochemistry Journal 307, 609-616 (1995).
[4]. van Corven, E.J., van Rijswijk, A., Jalink, K., et al. Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin. Biochemistry Journal 281, 163-169 (1992).

Chemical Properties

Cas No. 65528-98-5 SDF
Synonyms 1-Oleoyl LPA, Oleoyl-sn-3-Glycerophosphate
Chemical Name 1-O-9Z-octadecenoyl-sn-glyceryl-3-phosphoric acid
Canonical SMILES CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O
Formula C21H41O7P M.Wt 436.5
Solubility DMF: 2 mg/ml; DMSO: 2.5 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): 3 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.291 mL 11.4548 mL 22.9095 mL
5 mM 0.4582 mL 2.291 mL 4.5819 mL
10 mM 0.2291 mL 1.1455 mL 2.291 mL
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Related Video

    1-Oleoyl Lysophosphatidic Acid -GlpBio

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