15-Acetyldeoxy Nivalenol (Synonyms: 15-Acetyl Vomitoxin, 15-AcDON, Deoxynivalenol 15-acetate, DON 15-acetate) |
| Catalog No.GC19442 |
15-Acetyldeoxy Nivalenol은 곡물에서 발견되는 고독성 트리코테센이며, deoxynivalenol의 대사산물로 HepG2 세포에 독성을 나타냅니다.
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Cas No.: 88337-96-6
Sample solution is provided at 25 µL, 10mM.
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15-Acetyldeoxy nivalenol is a trichothecene mycotoxin produced by certain species of the fungus Fusarium, particularly those found on cereal crops. It is an acetylated derivative of 4-deoxy nivalenol that can be converted to DON in the body. 15-Acetyldeoxy nivalenol induces vomiting and anorexia in livestock and experimental animals and its toxicity compared with DON is dependent upon the route of administration. It also changes brain bioamine neurotransmitter levels in pigs and chickens.
References:
[1].Ajandouz, E.H., Berdah, S., Moutardier, V., et al. Hydrolytic fate of 3/15-acetyldeoxynivalenol in humans: Specific deacetylation by the small intestine and liver revealed using in vitro and ex vivo approaches Toxins (Basel) 8(8), E232 (2016).
[2]. Pestka, J.J., Lin, W.-S., and Miller, E.R. Emetic activity of the trichothecene 15-acetyldeoxynivalenol in swine Food Chem. Toxicol. 25(11), 855-888 (1987).
[3].Payros, D., Alazzane-Kpembi, I., Pierron, A., et al. Toxicology of deoxynivalenol and its acetylated and modified forms Arch. Toxicol. 90(12), 2931-2957 (2016).
[4].Bonnet, M.S., Roux, J., Mounien, L., et al. Advances in deoxynivalenol toxicity mechanisms: The brain as a target Toxins (Basel) 4(11), 1120-1138 (2012).
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