(±)16-HETE (Synonyms: (±)16-Hydroxyeicosatetraenoic Acid) |
| Catalog No.GC40434 |
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites.
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Cas No.: 128914-46-5
Sample solution is provided at 25 µL, 10mM.
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Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure. At a concentration of 2 µM the (S)-enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R)-isomer has negligible effects on ATPase activity.
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