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(±)-Ibuprofen-d3 (sodium salt) (Synonyms: DL-Ibuprofen-d3)

Catalog No.GC49515

An internal standard for the quantification of (±)-ibuprofen

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(±)-Ibuprofen-d3 (sodium salt) Chemical Structure

Cas No.: 1219805-09-0

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5 mg
US$107.00
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10 mg
US$185.00
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25 mg
US$480.00
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50 mg
US$853.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(±)-Ibuprofen-d3 is intended for use as an internal standard for the quantification of (±)-ibuprofen by GC- or LC-MS. (±)-Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) and non-selective COX inhibitor (IC50s = 2.6 and 1.3 µM for human recombinant COX-1 and COX-2, respectively).1 In vivo, (±)-ibuprofen inhibits late-phase formalin-induced paw licking in mice (ED50 = 6.1 mg/kg).2 It also inhibits acetic acid-induced writhing in mice (ED50 = 0.47 mg/kg). Formulations containing (±)-ibuprofen have been used in the treatment of fever and mild to severe pain.

1.Johnson, J.L., Wimsatt, J., Buckel, S.D., et al.Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledonsArch. Biochem. Biophys.324(1)26-34(1995) 2.Seguin, L., Le Marouille-Girardon, S., and Millan, M.J.Antinociceptive profiles of non-peptidergic neurokinin1 and neurokinin2 receptor antagonists: A comparison to other classes of antinociceptive agentPain61(2)325-343(1995)

Chemical Properties

Cas No. 1219805-09-0 SDF Download SDF
Synonyms DL-Ibuprofen-d3
Canonical SMILES [O-]C(C(C1=CC=C(C=C1)CC(C)C)C([2H])([2H])[2H])=O.[Na+]
Formula C13H14D3O2 • Na M.Wt 231.3
Solubility DMF: 30 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 2 mg/ml Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 4.3234 mL 21.6169 mL 43.2339 mL
5 mM 0.8647 mL 4.3234 mL 8.6468 mL
10 mM 0.4323 mL 2.1617 mL 4.3234 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Average Rating: 5 ★★★★★ (Based on Reviews and 18 reference(s) in Google Scholar.)

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