1G244 |
| Catalog No.GC39296 |
1G244는 IC50이 각각 12nM 및 84nM인 강력한 DPP8/9 억제제입니다. 1G244는 DPPIV 및 DPPII를 억제하지 않습니다. 1G244는 다발성 골수종 세포에서 세포 사멸을 유도하고 항골수종 효과가 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 847928-32-9
Sample solution is provided at 25 µL, 10mM.
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1G244 is a potent DPP8/9 inhibitor with IC50s of 12 nM and 84 nM, respectively. 1G244 does not inhibit DPPIV and DPPII. 1G244 induces apoptosis in multiple myeloma cells and has anti-myeloma effects[1][2].
[1]. Sato T, et al. DPP8 is a novel therapeutic target for multiple myeloma. Sci Rep. 2019 Dec 2;9(1):18094. [2]. Leen Heirbaut, et al. Probing for improved selectivity with dipeptidederived inhibitors of dipeptidyl peptidases 8 and 9: the impact of P1-variation. MedChemComm. 2016, 7.
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
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