(1R,2R)-2-PCCA(hydrochloride) |
| Catalog No.GC30855 |
(1R,2R)-2-PCCA(염산염)은 2-PCCA의 부분입체 이성질체이며, 무세포 분석에서 3nM, 세포 분석에서 603nM의 EC50으로 강력한 GPR88 수용체 작용제로 작용합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1609563-71-4
Sample solution is provided at 25 µL, 10mM.
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(1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC50 of 3 nM.
(1R,2R)-2-PCCA hydrochloride is a potent GPR88 receptor agonist, with an EC50 of 3 nM[1]. (1R,2R)-2-PCCA inhibits GPR88-mediated cAMP production through a Gαi-coupled pathway, with an EC50 of 56 nM in HEK293 cells stably expressing the human GPR88 receptor and the GloSensor-22F cAMP construct[2].
[1]. Bi, Yingzhi, et al. Modulators of G Protein-Coupled Receptor 88. US 20110251204 A1. [2]. Jin C, et al. Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies. ACS Chem Neurosci. 2016 Oct 19;7(10):1418-1432.
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