>>Signaling Pathways>> Ox Stress Reagents>> Lipid Peroxidation>>2-HOBA

2-HOBA (Synonyms: 2-(Aminomethyl)phenol, 2-Hydroxybenzylamine, NSC 127870)

Catalog No.GC40503

선택적 디카르보닐 제거제인 2-HOBA(2-HOBA)는 항산화제이자 자유 라디칼과 이소레부글란딘(IsoLG)의 제거제입니다.

Products are for research use only. Not for human use. We do not sell to patients.

2-HOBA Chemical Structure

Cas No.: 932-30-9

Size 가격 재고 수량
250mg
US$25.00
재고 있음
500mg
US$48.00
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1g
US$76.00
재고 있음
5g
US$406.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Description of 2-HOBA

2-HOBA is an isoketal scavenger. In vivo, 2-HOBA reduces angiotensin II-induced increases in blood pressure and decreases isoketal accumulation in mouse heart and vasculature. It also prevents angiotensin II-induced collagen IV accumulation and renal damage in mouse kidney. 2-HOBA has also been used as a building block in the synthesis of saluretic agents and task-specific ionic liquids.

Chemical Properties of 2-HOBA

Cas No. 932-30-9 SDF
Synonyms 2-(Aminomethyl)phenol, 2-Hydroxybenzylamine, NSC 127870
Canonical SMILES OC1=C(CN)C=CC=C1
Formula C7H9NO M.Wt 123.2
Solubility DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 2-HOBA

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 8.1169 mL 40.5844 mL 81.1688 mL
5 mM 1.6234 mL 8.1169 mL 16.2338 mL
10 mM 0.8117 mL 4.0584 mL 8.1169 mL
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In vivo Formulation Calculator (Clear solution) of 2-HOBA

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Review for 2-HOBA

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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