2-Methylquinazolin-4-ol |
| Catalog No.GC62781 |
2-메틸퀴나졸린-4-올은 1.1μM의 Ki를 갖는 강력한 경쟁적 폴리(ADP-리보스) 합성효소 억제제입니다.
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Cas No.: 1769-24-0
Sample solution is provided at 25 µL, 10mM.
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2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM[1][2].
2-Methylquinazolin-4-ol inhibits ATCase in a concentration-dependent manner[1].
2-Methylquinazolin-4-ol (0.2-1 mg; i.g.; for two days) inhibits ATCase in a dosedependent manner in vivo[2].
[1]. S Yoshida, et al. Production of 2-methyl-4[3H]-quinazolinone, an inhibitor of poly(ADP-ribose) synthetase, by bacterium. J Antibiot (Tokyo). 1991 Jan;44(1):111-2.
[2]. Mahmoud Balbaa, et al. Inhibition of mammalian aspartate transcarbamylase by quinazolinone derivatives. J Enzyme Inhib Med Chem. 2008 Aug;23(4):483-92.
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