>>Signaling Pathways>> Apoptosis>>2'-O-Methylguanosine

2'-O-Methylguanosine

Catalog No.GC41612

2'-O-메틸구아노신은 tRNA 구아노신-2'-O-메틸트랜스퍼라제의 작용에 의해 tRNA에서 생성되는 변형된 뉴클레오시드입니다.

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2'-O-Methylguanosine Chemical Structure

Cas No.: 2140-71-8

Size 가격 재고 수량
250mg
US$77.00
재고 있음
500mg
US$128.00
재고 있음
1g
US$214.00
재고 있음

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고객 리뷰

Based on customer reviews.

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

2'-O-Methylguanosine is a modified nucleoside that is produced in tRNAs by the action of tRNA guanosine-2'-O-methyltransferase, using S-adenosyl-L-methionine as a substrate. Through its interaction with other modified nucleosides, 2'-O-methylguanosine is thought to stabilize the structure of the tRNA. 2'-O-Methylguanosine can also be found in rRNA. Normal and modified nucleosides, including 2'-O-methylguanosine, have been shown to be secreted by a natural suppressor cell line and induce apoptosis in K562/Molt4 target cells.

Chemical Properties

Cas No. 2140-71-8 SDF
Canonical SMILES O=C1C2=C(N([C@H]3[C@H](OC)[C@H](O)[C@@H](CO)O3)C=N2)N=C(N)N1
Formula C11H15N5O5 M.Wt 297.3
Solubility 0.1 M HCl: 10 mg/ml,DMF: 50 µ g/ml,DMSO: 12 mg/ml,Ethanol: 50 µ g/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.3636 mL 16.818 mL 33.6361 mL
5 mM 0.6727 mL 3.3636 mL 6.7272 mL
10 mM 0.3364 mL 1.6818 mL 3.3636 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

리뷰

Review for 2'-O-Methylguanosine

Average Rating: 5 ★★★★★ (Based on Reviews and 31 reference(s) in Google Scholar.)

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