>>Infectious Disease>> Parasitic Diseases>>(25S)-δ7-Dafachronic Acid

(25S)-δ7-Dafachronic Acid (Synonyms: UPF1404)

Catalog No.GC40803

During unfavorable environmental conditions, C.

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(25S)-δ7-Dafachronic Acid Chemical Structure

Cas No.: 949004-12-0

Size 가격 재고 수량
100μg
US$459.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival. DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans. DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. (25S)-δ7-Dafachronic acid is a sterol-derived hormone that acts as a ligand of DAF-12 with an EC50 value of 23 nM. At 50 nM, (25S)-δ7-Dafachronic acid inhibits the dauer-promoting activity of DAF-12, blocking the formation of infective larvae in several parasitic nematodes in favor of reproductive maturation to adults. Thus, selective ligand modulators of DAF-12 are a potential therapeutic approach to stop larvae progression during parasitic infection.

Chemical Properties

Cas No. 949004-12-0 SDF
Synonyms UPF1404
Canonical SMILES O=C1CC[C@@]2(C)C(CC=C3C2CC[C@@]4(C)C3CC[C@@H]4[C@@H](CCC[C@H](C)C(O)=O)C)C1
Formula C27H42O3 M.Wt 414.6
Solubility DMF: 5 mg/ml,DMSO: 2.5 mg/ml,Ethanol: 12.5 mg/ml,Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.412 mL 12.0598 mL 24.1196 mL
5 mM 0.4824 mL 2.412 mL 4.8239 mL
10 mM 0.2412 mL 1.206 mL 2.412 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 23 reference(s) in Google Scholar.)

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