>>Signaling Pathways>> Neuroscience>> Seizure Disorders>>3,4-Dihydroquinolin-2(1H)-one

3,4-Dihydroquinolin-2(1H)-one

Catalog No.GC46557

A building block

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3,4-Dihydroquinolin-2(1H)-one Chemical Structure

Cas No.: 553-03-7

Size 가격 재고 수량
1 g
US$47.00
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5 g
US$168.00
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10 g
US$312.00
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25 g
US$659.00
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Sample solution is provided at 25 µL, 10mM.

Description of 3,4-Dihydroquinolin-2(1H)-one

3,4-Dihydroquinolin-2(1H)-one is a building block.1,2 It has been used in the synthesis of compounds with antidepressant and anticonvulsant activities, as well as dual ligands of sigma (σ) receptors and the NMDA receptor GluN2b subunit that have antioxidant and neuroprotective properties.

1.Deng, X.-Q., Song, M.-X., Zheng, Y., et al.Design, synthesis and evaluation of the antidepressant and anticonvulsant activities of triazole-containing quinolinonesEur. J. Med. Chem.73217-224(2014) 2.Zampieri, D., Fortuna, S., Calabretti, A., et al.Discovery of new potent dual sigma receptor/GluN2b ligands with antioxidant property as neuroprotective agentsEur. J. Med. Chem.180268-282(2019)

Chemical Properties of 3,4-Dihydroquinolin-2(1H)-one

Cas No. 553-03-7 SDF
Canonical SMILES O=C1NC2=C(CC1)C=CC=C2
Formula C9H9NO M.Wt 147.2
Solubility DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 3,4-Dihydroquinolin-2(1H)-one

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 6.7935 mL 33.9674 mL 67.9348 mL
5 mM 1.3587 mL 6.7935 mL 13.587 mL
10 mM 0.6793 mL 3.3967 mL 6.7935 mL
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In vivo Formulation Calculator (Clear solution) of 3,4-Dihydroquinolin-2(1H)-one

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 22 reference(s) in Google Scholar.)

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