>>Signaling Pathways>> Proteases>> Endogenous Metabolite>>4-hydroxy Nonenal

4-hydroxy Nonenal (Synonyms: 4-HNE)

Catalog No.GC42410

지질 과산화 생성물

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4-hydroxy Nonenal Chemical Structure

Cas No.: 75899-68-2

Size 가격 재고 수량
10mM (in 1mL DMSO)
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1mg
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5mg
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10mg
US$133.00
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25mg
US$252.00
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50mg
US$406.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

4-하이드록시노넨알은 아라키돈산과 같은 산화된 ω-6 다중 불포화 지방산에서 유래한 지질 과산화 생성물입니다. 4-하이드록시노넨알은 지질 과산화의 표지자로 널리 사용됩니다. 이 화합물은 세포 독성, 성장 억제 활성, 유전 독성 및 화학적인 운동 활성 등 다양한 생물학적 활동을 나타내며, 10~50 µM에서 미트콘드리아로부터 프로옥시던트 유도 카르슘 방출을 억제합니다.

References:
[1]. Pryor, W.A., and Porter, N.A. Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids Free Radical Biology & Medicine 8, 541-543 (1990).
[2]. Esterbauer, H., Schaur, R.J., and Zoliner, H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydes Free Radical Biology & Medicine 11, 81-128 (1991).
[3]. Sodum, R.S., and Chung, F.L. 1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal Cancer Research 48, 320-323 (1988).

Chemical Properties

Cas No. 75899-68-2 SDF
Synonyms 4-HNE
Chemical Name (±)-4-hydroxy-2E-nonenal
Canonical SMILES CCCCCC(O)\C=C\C=O
Formula C9H16O2 M.Wt 156.2
Solubility 50mg/mL in DMSO, 50mg/mL in DMF, 50mg/mL Ethanol Storage -20°C, protect from light.
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 6.402 mL 32.0102 mL 64.0205 mL
5 mM 1.2804 mL 6.402 mL 12.8041 mL
10 mM 0.6402 mL 3.201 mL 6.402 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Related Video

    4-hydroxy Nonenal-GlpBio

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