>>Signaling Pathways>> Chromatin/Epigenetics>> HDAC>>4-iodo-SAHA

4-iodo-SAHA (Synonyms: ISAHA)

Catalog No.GC17005

4-Iodo-SAHA(1k)는 Skbr3, HT29, U937, JA16 및 HL60에 대해 EC50이 1.1, 0.95, 0.12, 0.24, 0.85 및 1.3μM인 경구 활성 클래스 I 및 클래스 II 히스톤 데아세틸라제(HDAC) 억제제입니다. , 각각. 4-Iodo-SAHA(1k)는 암 연구에 사용할 수 있습니다.

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4-iodo-SAHA Chemical Structure

Cas No.: 1219807-87-0

Size 가격 재고 수량
10mM (in 1mL DMSO)
US$35.00
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50mg
US$53.00
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100mg
US$98.00
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250mg
US$222.00
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500mg
US$443.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

4-iodo-SAHA is a hydrophobic derivative of SAHA, the class I and class II histone deacetylase (HDAC) inhibitor [1].

The reversible acetylation of lysine residues in histone plays an important role in transcriptional activation and repression. The regulation of these post-translational modifications is balanced by histone acetyltransferase (HAT) and histone deacetylase (HDAC) activities. HDACs are also involved in reversible acetylation of non-histone proteins [1].

4-iodo-SAHA is a histone deacetylase (HDAC) inhibitor. In SKBR3-breast-derived cell line, 4-iodo-SAHA inhibited cell proliferation with EC50 value of 1.1 μM. In HT29 colon-derived cell line, leukemia-derived U937 tumor cell line, JA16, HL60 and K562 cell lines, 4-iodo-SAHA inhibited cell proliferation with EC50 values of 0.95, 0.12, 0.24, 0.85 and 1.3 μM, respectively. 4-iodo-SAHA is 10-fold more potent as an inhibitor of U937 leukemia cell proliferation compared to SAHA (0.12 μM versus 1.2 μM). In SKBR3 cells, 4-iodo-SAHA reduced acetylated H4 and p21 levels [1].

Reference:
[1].  Salmi-Smail C, Fabre A, Dequiedt F, et al. Modified cap group suberoylanilide hydroxamic acid histone deacetylase inhibitor derivatives reveal improved selective antileukemic activity. J Med Chem. 2010 Apr 22;53(8):3038-47.

Chemical Properties

Cas No. 1219807-87-0 SDF
Synonyms ISAHA
Chemical Name N1-hydroxy-N8-(4-iodophenyl) octanediamide
Canonical SMILES IC1=CC=C(NC(CCCCCCC(NO)=O)=O)C=C1
Formula C14H19IN2O3 M.Wt 390.2
Solubility ≥ 1.67mg/mL in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.5628 mL 12.8139 mL 25.6279 mL
5 mM 0.5126 mL 2.5628 mL 5.1256 mL
10 mM 0.2563 mL 1.2814 mL 2.5628 mL
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리뷰

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Average Rating: 5 ★★★★★ (Based on Reviews and 11 reference(s) in Google Scholar.)

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