>>Signaling Pathways>> Neuroscience>> 5-HT Receptor>>(4E)-SUN9221

(4E)-SUN9221

Catalog No.GC32644

(4E)-SUN9221은 항고혈압 및 항혈소판 응집 활성을 갖는 α1-아드레날린성 수용체 및 5-HT2 수용체의 강력한 길항제입니다.

Products are for research use only. Not for human use. We do not sell to patients.

(4E)-SUN9221 Chemical Structure

Cas No.: 222318-55-0

Size 가격 재고 수량
1mg
US$1,324.00
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5mg
US$2,979.00
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10mg
US$5,066.00
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20mg
US$8,935.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities.

(4E)-SUN9221 potently inhibits collagen-, ADP- and epinephrine-induced platelet aggregation, with IC50s of 10 nM, 35 nM, 14 nM, respectively, in human platelet-rich plasma (PRP). (4E)-SUN9221 displays potent α1-adrenergic antagonist activity (pA2 =8.89±0.21) and 5-HT2 antagonist activity (pA2 =8.74±0.22)[1].

(4E)-SUN9221 (1, 3, 10 mg/kg, p.o.) reduces the blood pressure in a dose-dependent manner in conscious spontaneously hypertensive rats (SHR). (4E)-SUN9221 (3 mg/kg) exhibits antihypertensive activity in SHR[1].

[1]. Mizuno A, et al. Synthesis and pharmacological evaluation of pyrroloazepine derivatives as potent antihypertensive agents with antiplatelet aggregation activity. Chem Pharm Bull (Tokyo). 1999 Feb;47(2):246-56.

Chemical Properties

Cas No. 222318-55-0 SDF
Canonical SMILES O=C(C1=C/2C=CN1CCCCN3CCC(C(C4=CC=C(F)C=C4)=O)CC3)N(C)CCC2=N/O
Formula C25H31FN4O3 M.Wt 454.54
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.2 mL 11.0001 mL 22.0003 mL
5 mM 0.44 mL 2.2 mL 4.4001 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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리뷰

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Average Rating: 5 ★★★★★ (Based on Reviews and 39 reference(s) in Google Scholar.)

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