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4SC-202

Catalog No.GC12667

4SC-202(4SC-202)는 HDAC의 IC50이 각각 1.20 μM, 1.12 μM 및 0.57 &88 HD88895인 선택적 클래스 I HDAC 억제제입니다. 또한 라이신 특이적 디메틸라제 1(LSD1)에 대한 억제 활성을 나타냅니다.

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4SC-202 Chemical Structure

Cas No.: 1186222-89-8

Size 가격 재고 수량
5mg
US$69.00
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10mg
US$102.00
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50mg
US$325.00
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100mg
US$522.00
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500mg
US$1,730.00
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1g
US$2,657.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

4SC-202 is a selective, potent and orally available inhibitor of histone deacetylases (HDAC) specific for class I HDAC isoenzymes with an IC50 value of about 1μM [1].

4SC-202 has been reported to selectively inhibit the recombinant class I HDAC isoenzymes with IC50 values of 1.2μM, 1.12μM and 0.57μM for HDAC-1, HDAC-2 and HDAC-3, respectively. In vitro studies, 4SC-202 has been revealed to induce hyperacetylation of histone H3 in a concentration-dependent fashion with an EC50 values of 1.1μM in HeLa and RKO cell lines. In addition, 4SC-202 has been demonstrated to induce a G2/M cell cycle arrest and enhance in sub G1 cells. In other words, 4SC-202 can induce the apoptotic in NSCLS cell lines. 4SC-202 has been noted to suppress proliferative activity in human cancer cell lines with a mean IC50 of 0.7μM.

In vivo studies, 4SC-202 has shown a good tolerability and dose-dependent effect on anti-tumour activity compared with other inhibitors in the A549NSCLC xenograft model and the RKO27 colon carcinoma model [1].

References:
[1] Henning S W, Doblhofer R, Kohlhof H, et al. 178 Preclinical characterization of 4SC-202, a novel isotype specific HDAC inhibitor[J]. European Journal of Cancer Supplements, 2010, 8(7): 61.

Chemical Properties

Cas No. 1186222-89-8 SDF
Formula C30H29N5O6S2 M.Wt 619.71
Solubility ≥ 62mg/mL in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.6137 mL 8.0683 mL 16.1366 mL
5 mM 0.3227 mL 1.6137 mL 3.2273 mL
10 mM 0.1614 mL 0.8068 mL 1.6137 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 11 reference(s) in Google Scholar.)

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