>>Signaling Pathways>> Chromatin/Epigenetics>> DNA Methyltransferase>>5-Fluoro-2'-deoxycytidine

5-Fluoro-2'-deoxycytidine

Catalog No.GC61662

5-플루오로-2'-데옥시시티딘, 플루오로피리미딘 뉴클레오시드 유사체는 DNA 메틸트랜스퍼라제(DNMT) 억제제입니다. 5-Fluoro-2'-deoxycytidine은 강력한 thymidylate synthase 억제제 5-fluoro-2'-dUMP의 종양 선택성 전구약물입니다.

Products are for research use only. Not for human use. We do not sell to patients.

5-Fluoro-2'-deoxycytidine Chemical Structure

Cas No.: 10356-76-0

Size 가격 재고 수량
5 mg
US$46.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

5-Fluoro-2'-deoxycytidine, a fluoropyrimidine nucleoside analogue, is a DNA methyltransferase (DNMT) inhibitor. 5-Fluoro-2'-deoxycytidine is a tumor-selective prodrug of the potent thymidylate synthase inhibitor 5-fluoro-2′-dUMP[1][2].

[1]. Beumer JH, et, al. Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine in mice. Clin Cancer Res. 2006 Dec 15;12(24):7483-91. [2]. Osterman DG, et, al. 5-Fluorocytosine in DNA is a mechanism-based inhibitor of HhaI methylase. Biochemistry. 1988 Jul 12;27(14):5204-10.

Chemical Properties

Cas No. 10356-76-0 SDF
Canonical SMILES OC[C@@H]1[C@@H](O)C[C@@H](O1)N2C(N=C(N)C(F)=C2)=O
Formula C9H12FN3O4 M.Wt 245.21
Solubility Storage 4°C, protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 4.0781 mL 20.3907 mL 40.7814 mL
5 mM 0.8156 mL 4.0781 mL 8.1563 mL
10 mM 0.4078 mL 2.0391 mL 4.0781 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

리뷰

Review for 5-Fluoro-2'-deoxycytidine

Average Rating: 5 ★★★★★ (Based on Reviews and 38 reference(s) in Google Scholar.)

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