(5Z,2E)-CU-3 |
| Catalog No.GC60397 |
(5Z,2E)-CU-3은 0.6μM의 IC50 값을 갖는 DGK의 α-동종효소에 대한 강력하고 선택적인 억제제이며, 0.48mM의 Km 값으로 ATP에 대한 DGKα의 친화도를 경쟁적으로 억제합니다. (5Z,2E)-CU-3은 촉매 영역을 목표로 하지만 DGKα의 조절 영역은 목표로 하지 않습니다. (5Z,2E)-CU-3은 항종양 및 면역원성 효과가 있으며 암세포의 세포자멸사 및 T 세포의 활성화를 향상시킵니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1815598-71-0
Sample solution is provided at 25 µL, 10mM.
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(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].
[1]. Liu K, et al. A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J Lipid Res. 2016 Mar;57(3):368-79.
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