653-47 hydrochloride |
Catalog No.GC62144 |
강화제인 653-47 염산염은 666-15의 cAMP-반응 요소 결합 단백질(CREB) 억제 활성을 상당히 강화합니다. 653-47 염산염은 또한 IC50이 26.3μM인 매우 약한 CREB 억제제입니다.
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Cas No.: 1224567-46-7
Sample solution is provided at 25 µL, 10mM.
653-47 hydrochloride, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 hydrochloride is also a very weak CREB inhibitor with IC50 of 26.3 μM[1].
653-47 (5-10 μM) synergistically inhibits CREB-mediated gene transcription with 666-15[1].
[1]. Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666-15. J Med Chem. 2019;62(24):11423-11429.
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