>>Signaling Pathways>> Neuroscience>> COX>> α-​Chaconine

α-​Chaconine

Catalog No.GC63267

α-Chaconine은 전사 수준에서 COX-2, IL-1β, IL-6 및 TNF-α의 발현을 억제합니다.

Products are for research use only. Not for human use. We do not sell to patients.

 α-​Chaconine Chemical Structure

Cas No.: 20562-03-2

Size 가격 재고 수량
1 mg
US$315.00
재고 있음
5 mg
US$1,125.00
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Based on customer reviews.

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects[1].

α-Chaconine attenuates the transcriptional activity of activator protein-1 (AP-1) by reducing the translocation and phosphorylation of c-Jun.α-Chaconine suppresses lipopolysaccharide-induced pro-inflammatory mediators via AP-1 inactivation in RAW 264.7 macrophages and protects mice from endotoxin shock.α-Chaconine also suppresses the phosphorylation of TGF-β-activated kinase-1 (TAK1), which lies upstream of MKK7/JNK signaling[1].

[1]. Lee KG, et al. α-Chaconine isolated from a Solanum tuberosum L. cv Jayoung suppresses lipopolysaccharide-induced pro-inflammatory mediators via AP-1 inactivation in RAW 264.7 macrophages and protects mice from endotoxin shock. Chem Biol Interact. 2015 Jun 25;235:85-94.

Chemical Properties

Cas No. 20562-03-2 SDF
Formula C45H73NO14 M.Wt 852.06
Solubility Storage
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.1736 mL 5.8681 mL 11.7363 mL
5 mM 0.2347 mL 1.1736 mL 2.3473 mL
10 mM 0.1174 mL 0.5868 mL 1.1736 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.

리뷰

Review for α-​Chaconine

Average Rating: 5 ★★★★★ (Based on Reviews and 17 reference(s) in Google Scholar.)

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