β-Amyrone (Synonyms: β-Amyron) |
| Catalog No.GC66340 |
β-Amyrone(β-Amyron)은 COX-2의 발현을 억제하여 항염증 활성을 갖는 트리테르펜 화합물이다. 821d96072c2d58d8970e76f526b0f6b8β-Amyrone은 항진균 활성뿐만 아니라 Chikungunya 바이러스에 대한 항바이러스 활성도 있습니다. 821d96072c2d58d8970e76f526b0f6b8β-Amyrone은 또한 α-글루코시다제 및 아세틸콜린에스테라제(AChE) 활성을 억제합니다. 821d96072c2d58d8970e76f526b0f6b8β-Amyrone은 염증, 감염 및 비만과 같은 질병 연구에 사용할 수 있습니다.821d96072c2d58d8970e76f526b0f6b8
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 638-97-1
Sample solution is provided at 25 µL, 10mM.
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β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity[1][2][3][4].
β-Amyrone (1.25-10 μg/mL, 24 h) inhibits on NO? production in LPS-stimulated J774 cells, with an IC50 value of 4.61 μg/mL, and has no obvious effect on cell viability[1].
β-Amyrone (10 μg/mL, 24 h) inhibits IL-6, IL-10 levels, and COX-2 expression in LPS-stimulated J774 cells[1].
β-Amyrone (0-235 μM, 7days) has antiviral activity in Vero cells against Chikungunya virus (CHIKV), with EC50 value of 86 uM[2].
β-Amyrone inhibits α-glucosidase, acetylcholinesterase (AChE) and fungal activity with IC50 values of 25 μM, 23 μM and 8 μg/mL, respectively[4].
Western Blot Analysis[1]
| Cell Line: | LPS (1 μg/mL)-stimulated J774 cells |
| Concentration: | 2.5, 5, 10 μg/mL |
| Incubation Time: | 24 h |
| Result: | Inhibited COX-2 expression in a concentration-dependent manner (approximately 90% reduction at 5 or 10 μg/ mL). |
β-Amyrone (local administration on ear, 0.1-0.6 mg/kg, a single dose) inhibits ear edema formation in phenol-induced edema mice[1].
| Animal Model: | Ear phenol-induced edema in Balb C mice[1] |
| Dosage: | 0.1, 0.3, 0.6 mg/kg, a single dose |
| Administration: | Local administration (20 ??L solution) on ear |
| Result: | Inhibited ear edema formation in a dose-related manner (47% inhibition at the dose of 0.6mg/kg). |
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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