>>Lipids>> Sterol Lipids>>δ14-Triamcinolone acetonide

δ14-Triamcinolone acetonide (Synonyms: 14,15-dehydro Triamcinolone acetonide, Triamcinolone acetonide Impurity B)

Catalog No.GC45238

δ14-Triamcinolone acetonide is a potential impurity found in commercial preparations of triamcinolone acetonide.

Products are for research use only. Not for human use. We do not sell to patients.

δ14-Triamcinolone acetonide Chemical Structure

Cas No.: 1260149-96-9

Size 가격 재고 수량
500μg
US$140.00
재고 있음
1mg
US$268.00
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5mg
US$1,124.00
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10mg
US$1,545.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

δ14-Triamcinolone acetonide is a potential impurity found in commercial preparations of triamcinolone acetonide. Triamcinolone acetonide is a synthetic corticosteroid. It decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model when used at a dose of 1.5 mg/kg prior to and following surgery for three days. Triamcinolone acetonide also decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 µl of a 40 mg/ml suspension is administered subconjunctivally. Formulations containing triamcinolone acetonide are used in the treatment of diabetic macular edema.

Chemical Properties

Cas No. 1260149-96-9 SDF
Synonyms 14,15-dehydro Triamcinolone acetonide, Triamcinolone acetonide Impurity B
Canonical SMILES O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)C3=C[C@]5([H])[C@@]4(C(CO)=O)OC(C)(C)O5)=C1
Formula C24H29FO6 M.Wt 432.5
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.3121 mL 11.5607 mL 23.1214 mL
5 mM 0.4624 mL 2.3121 mL 4.6243 mL
10 mM 0.2312 mL 1.1561 mL 2.3121 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

리뷰

Review for δ14-Triamcinolone acetonide

Average Rating: 5 ★★★★★ (Based on Reviews and 38 reference(s) in Google Scholar.)

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