A 286982 |
| Catalog No.GC15192 |
A 286982는 LFA-1/ICAM-1 결합 및 LFA-1 매개 세포 접착 분석에서 각각 44nM 및 35nM의 IC50을 갖는 강력하고 알로스테릭한 LFA-1/ICAM-1 상호작용 억제제입니다.
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Cas No.: 280749-17-9
Sample solution is provided at 25 µL, 10mM.
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A286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1; IC50 = 35 nM). [1] It inhibits adhesion of JY-8 cells to ICAM-1-coated microtiter plates (IC50 = 44 nM).
Reference:
[1]. Liu, G., Link, J.T., Pei, Z., et al. Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead. J. Med. Chem. 43(21), 4025-4040 (2000).
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